A Associação de Jovens Empresários de Fortaleza (AJE Fortaleza) lançou oficialmente, nesta semana, a campanha “Imposto Solidário”, uma iniciativa inovadora que visa sensibilizar empresas enquadradas no regime de Lucro Real a utilizarem até 2% do seu lucro operacional para doações a instituições de caridade, por meio de mecanismos legais de renúncia fiscal.
A proposta tem como objetivo mostrar que é possível transformar parte dos tributos devidos em ações concretas de impacto social, de forma totalmente legal, segura e inteligente. Ao aderir à campanha, as empresas podem contribuir diretamente para o fortalecimento de organizações que atuam em prol de crianças, adolescentes e causas sociais relevantes, sem qualquer custo adicional.
Segundo a AJE Fortaleza, muitas empresas desconhecem esse recurso fiscal disponível. A campanha “Imposto Solidário” pretende não apenas informar, mas também conectar empresários a projetos sociais sérios e devidamente habilitados para receber esses recursos.
“Com o ‘Imposto Solidário’, queremos mostrar que responsabilidade social e gestão fiscal eficiente podem andar juntas. As empresas têm a oportunidade de decidir onde parte do seu imposto será aplicado, ajudando diretamente instituições que mudam realidades em nossa cidade”, destacou Thiago Guimarães, coordenador geral da AJE Fortaleza.
O gerente do programa, Thomaz Marques, reforça que o incentivo fiscal já é previsto na legislação e representa uma estratégia eficaz de investimento social:
“Nosso objetivo é informar que esse mecanismo existe e está ao alcance das empresas do Lucro Real. É uma alternativa legal que permite transformar parte do imposto devido em investimento social. Além de beneficiar instituições que realizam um trabalho essencial, a empresa fortalece sua imagem institucional, engaja seus colaboradores e reforça seu compromisso com a responsabilidade social. Essa é uma das estratégias mais inteligentes e humanas do planejamento tributário — e poucas empresas aproveitam. Se você quer sair na frente, fala comigo”, afirma Thomaz Marques.
A campanha conta com uma rede de apoio técnico para orientar as empresas interessadas em participar, oferecendo suporte jurídico e contábil para garantir segurança em todo o processo.
Even though solely 12–14% of androstenedione is transformed peripherally to testosterone
(Horton and Tait, 1966; Bardin and Lipsett, 1967), this amount accounts for about half the circulating testosterone in the women. As the peripheral contribution to blood testosterone is
way larger in the young grownup women than the boys, ingestion of modest quantities of androstenedione, DHEA or androstenediol (the
pure steroid or the Δ4 analogue) is more doubtless to significantly raise circulating testosterone.
There are modest-to-large will increase in circulating testosterone following androstenedione administration to ladies (Leder et al., 2002;
Kicman et al., 2003a; Bassindale et al., 2004; Brown et al.,
2004). Ladies who chronically administer massive doses of weaker androgens that might
be transformed to more potent steroids could be
expected to endure from virilizing effects. In 2004, the FDA (Food and Drug Administration),
as a half of its public well being mission, sent warning letters to 23 firms within the Usa requesting them to cease distributing androstenedione as dietary supplements (FDA, 2004).
Parenteral preparations don’t require a 17α-alkyl group however often the 17β-hydroxyl group is esterified with an acid moiety (van der Vies, 1993)
to forestall rapid absorption from the oily car, usually arachis oil plus a small quantity
of benzyl alcohol.
Medical experts can help navigate the complexities of steroid use and
its consequences. Individuals should understand that utilizing testosterone for performance enhancement
is different from reliable TRT. Whether Or Not you are
tempted by steroids or just want to perceive the details, this guide will help you make knowledgeable decisions about
your fitness journey.
Typically, it’s males of their mid to late 30’s who use anabolic best steroids for cutting fat – https://rockersinfo.com/pag/deca_durabolin_bodybuilding__uses__dosage.html – non-medically probably the most 11.
In 2022, an estimated zero.8% of 8th graders, zero.5% of tenth
graders, and 1.3% of twelfth graders reported misusing anabolic steroids up to now 12 months 31.
Urinalysis is by far the most reliable testing methodology, because the amount of time an anabolic
steroid or drug remains detectable in one’s system is the longest in an individual’s urine, especially in the
case of the metabolites of that compound. Whereas blood testing can additionally be
quite reliable, it falls in need of urinalysis because of the reality that anabolic steroids bear extensive biotransformation through the liver (hepatic biotransformation) as well as through the
kidneys (renal). Metabolites are the products of the body’s metabolism of assorted substances and compounds (in this case,
anabolic steroids). The metabolism of compounds within the physique, similar to
anabolic steroids, leads to changes to the unique chemical structure (or it could
additionally end in byproducts).
But one other examine, administering 1.000 mg testosterone undecanoate each 10–14 weeks (titrated to testosterone levels)
for two years, reported a clitoral size of
two.zero, 3.2, three.3, three.6, and three.eight cm at baseline, three,
6, 12 and 24 months of remedy (228). Clitoral dimension was
unaffected by a lower dosage of 25 mg testosterone enanthate weekly
for twenty-four weeks in hysterectomized girls (224). Thus,
in distinction with dysphonia and hirsutism, there appears to
be the next threshold of androgenic action required for this side impact to
occur.
Nonetheless, it ought to be appreciated that the accuracy of the equation is
based on the idea that serum creatinine levels accurately mirror the GFR
– which is uncertain in this explicit population. Creatinine is, for essentially the
most part, a product of the spontaneous nonenzymatic degradation of creatine (Cr) and creatine phosphate
(PCr) (159). The total conversion price for the whole Cr pool (Cr + PCr) is (almost) fixed and roughly 1.7% day
by day. Given that almost all the body’s creatine is saved in skeletal muscle, a
rise in muscle mass increases the every day production of creatinine and can subsequently
elevate serum creatinine levels with out impacting GFR.
The eGFR based mostly on serum creatinine ranges is subsequently an underestimate in muscular populations.
It appears appropriate to manage dyslipidemia in (long-term) AAS users
based on present pointers (151) simply as in some other patient.
Risk estimation using algorithms similar to SCORE2 may underestimate danger because certain unwanted facet effects of AAS
use, such as the detrimental changes to cardiac construction and function they elicit, might act as
threat modifiers.
With an estimated international lifetime prevalence price of three.3% (6.4% for males
and 1.6% for females) (2), nearly each practising physician will provide care for an AAS consumer sooner or later of their profession. Although, after all, the AAS user won’t necessarily disclose his
use of AAS or present with unwanted effects attributable to it.
This review subsequently supplies a complete overview of this class of hormones’ fundamental
pharmacology and unwanted effects. Throughout this evaluate, we point
out remedy options for several unwanted facet effects;
these should not be thought of strict suggestions, as they
are largely a reflection of how AAS users self-medicate or
what is known from the literature. It remains debatable whether or not physicians should medically
goal unwanted effects of AAS use. Obviously, discontinuing AAS would
be the preferred solution for virtually each side effect.
In research, 280 mg/week of testosterone enanthate had a very slight negative
effect on HDL ldl cholesterol after 12 weeks (4). Legal alternate options echo the sentiment of steroid benefits without
the legal quagmires or well being gambles—a middle floor for individuals who prioritize righteousness and well-being on par with gains.
Classification of a side effects’ chance is based on skilled opinion of
the authors.
The total medical results, nevertheless, are crystal clear –
first and foremost the muscle-building effect pursued by AAS customers.
Extra current well-designed trials continued to offer additional assist for the potent muscle-building effects of AAS
that had already been acknowledged by athletes for
many years (15, 22, 35–38). Anabolic-androgenic steroids
(AAS) are artificial derivatives of testosterone used to increase muscle
mass and enhance athletic efficiency. Their effects span muscular, cardiovascular, endocrine, and psychological techniques, usually with each
vital advantages and severe adverse penalties. Correct therapeutic use and dealing with illegal
misuse of anabolic steroids require an interprofessional
team effort. In addressing illicit use, all members need to concentrate on the signs of steroid misuse and
be prepared to counsel as necessary to try to resolve the problem.